SHTN1 Polyclonal Antibody | G-AB-06075

SHTN1 Polyclonal Antibody | G-AB-06075 | Gentaur Antibodies

Overview: Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.

Category Type: Polyclonal Antibody

Research Areas: Neuroscience

Synonyms: DKFZp686A0439, hypothetical protein FLJ11122, Kiaa1598, MGC40476, Putative uncharacterized protein KIAA1598, Shootin 1, Shootin-1, SHOT1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP001120683

Clonality: Polyclonal

Immunogen: Synthetic peptide of human SHTN1

Clone #:

Conjugation: Unconjugated

Swissprot: A0MZ66

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 0.48 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:100, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

SHTN1 Polyclonal Antibody DataSheet