SIGLEC12 Polyclonal Antibody | G-AB-12249

SIGLEC12 Polyclonal Antibody | G-AB-12249 | Gentaur Antibodies

Overview: Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas: Immunology

Synonyms: SIGLEC12, S2V, SIGLECL1, SLG, Siglec-XII

Reactivity: Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 89858

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human SIGLEC12 (NP_443729.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q96PQ1

Santa Cruz:

Calculated MW: 51 kDa/64 kDa

Observed MW: 80 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

SIGLEC12 Polyclonal Antibody DataSheet