SIRT1 Polyclonal Antibody | G-AB-05230
Gentaur Antibodies
- SKU:
- G-AB-05230
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
SIRT1 Polyclonal Antibody | G-AB-05230 | Gentaur Antibodies
Overview: SIRT1, also named as SIR2L1, contains a deacetylase sirtuin-type domain and belongs to the sirtuin family. It regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. SIRT1 in particular initiates several signalling events relevant to cardioprotection, including: activation of endothelial nitric oxide synthase, insulin receptor signalling, and autophagy. In addition SIRT1 activation elicits resistance to oxidative stress via regulation of transcription factors and co-activators such as FOXO, Hif-2a, and NF-kB. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lysine 382.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Microbiology, Tags & Cell Markers
Synonyms: 75SirT1, hSIR2, hSIRT1, HST2, S. cerevisiae, homolog of, NAD dependent deacetylase sirtuin 1, NAD dependent protein deacetylase sirtuin 1, OTTHUMP00000198111, OTTHUMP00000198112, Regulatory protein SIR2 homolog 1, SIR1, SIR2, SIR2 like 1, SIR2 like protein 1, SIR2, S.cerevisiae, homolog-like 1, SIR2-like protein 1, SIR2ALPHA, SIR2L1, Sirt1, SirtT1 75 kDa fragment, Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) , Sirtuin 1, Sirtuin type 1
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #:
Clonality: Polyclonal
Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse SIRT1
Clone #:
Conjugation: Unconjugated
Swissprot: Q96EB6, Q923E4, Q96EB6,
Santa Cruz:
Calculated MW:
Observed MW:
Concentration: 0.57 mg/mL
Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
Purification method: Affinity purification
Application: IHC
Dilution: IHC 1:200-1:800
Storage: Store at -20°C. Avoid freeze / thaw cycles.