SKP2 Polyclonal Antibody | G-AB-11832
- 3 to 5 Working Days
- Human, Mouse, Rat
SKP2 Polyclonal Antibody | G-AB-11832 | Gentaur Antibodies
Overview: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box) , which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19) . In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Cell Biology, Cardiovascular
Synonyms: SKP2, FBL1, FBXL1, FLB1, p45
Reactivity: Human, Mouse, Rat
Gene ID: 6502
Immunogen: A synthetic peptide of human SKP2 (NP_005974.2) .
Calculated MW: 23 kDa/46 kDa/47 kDa
Observed MW: 45 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.