SLAMF7 Polyclonal Antibody | G-AB-10831

SLAMF7 Polyclonal Antibody | G-AB-10831 | Gentaur Antibodies

Overview: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform1mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418) . Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536) . In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity) . May play a role in lymphocyte adhesion (PubMed:11802771) . In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528) .

Category Type: Polyclonal Antibody

Research Areas: Immunology

Synonyms: SLAMF7, 19A, CD319, CRACC, CS1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 57823

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human SLAMF7 (NP_067004.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9NQ25

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

SLAMF7 Polyclonal Antibody DataSheet