SLC1A6 Polyclonal Antibody | G-AB-02736

SLC1A6 Polyclonal Antibody | G-AB-02736 | Gentaur Antibodies

Overview: Excitatory Amino Acid Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings. EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, a process that is essential for terminating the postsynaptic action of glutamate. The re-uptake of amino acid neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, which is caused by the accumulation of amino acid neurotransmitters. EAAT4 is an aspartate/glutamate transporter that is expressed predominantly in the cerebellum. The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, and has a pharmacologic profile consistent with previously described cerebellar transport activities. EAAT5 is a glutamate transporter coupled to a chloride conductance which is expressed primarily in retina. Although EAAT5 shares the structural homologies of the EAAT family, a novel feature of the EAAT5 sequence is a carboxy-terminal motif previously identified in N-ethyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering.

Category Type: Polyclonal Antibody

Research Areas: Neuroscience

Synonyms: Excitatory amino acid transporter 4, High affinity neuronal glutamate transporter, MGC33092, MGC43671, Sodium dependent glutamate/aspartate transporter, Solute carrier family 1 (high affinity aspartate/glutamate transporter) member 6, Solute carrier family 1 member 6

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_005062

Clonality: Polyclonal

Immunogen: Synthetic peptide of human SLC1A6

Clone #:

Conjugation: Unconjugated

Swissprot: P48664

Santa Cruz: sc-18775/sc-50403

Calculated MW: 62 kDa

Observed MW:

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

SLC1A6 Polyclonal Antibody DataSheet