SPAG1 Polyclonal Antibody | G-AB-02860

SPAG1 Polyclonal Antibody | G-AB-02860 | Gentaur Antibodies

Overview: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP Signal Transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.

Category Type: Polyclonal Antibody

Research Areas: Developmental Biology

Synonyms: CILD28, FLJ32920, HSD-3.8, Infertility related sperm protein Spag 1, SP75, SPAG1, Sperm associated antigen 1, Tetratricopeptide repeat-containing protein, TPIS, TPR containing protein involved in spermatogenesis

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_003105

Clonality: Polyclonal

Immunogen: Synthetic peptide of human SPAG1

Clone #:

Conjugation: Unconjugated

Swissprot: Q07617

Santa Cruz: sc-98146

Calculated MW: 104 kDa

Observed MW:

Concentration: 0.3 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, ELISA

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

SPAG1 Polyclonal Antibody DataSheet