STAT5A Polyclonal Antibody | G-AB-11834

STAT5A Polyclonal Antibody | G-AB-11834 | Gentaur Antibodies

Overview: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X (L) , which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms: MGF, STAT5, STAT5A

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 6776

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human STAT5A (NP_003143.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P42229

Santa Cruz:

Calculated MW: 86 kDa/90 kDa

Observed MW: 90 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IF

Dilution: WB 1:500-1:2000 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

STAT5A Polyclonal Antibody DataSheet