TAB1 Polyclonal Antibody | G-AB-10810

TAB1 Polyclonal Antibody | G-AB-10810 | Gentaur Antibodies

Overview: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha) , and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Immunology, Signal Transduction

Synonyms: TAB1, 3'-Tab1, MAP3K7IP1

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 10454

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human TAB1 (NP_006107.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q15750

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:10-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

TAB1 Polyclonal Antibody DataSheet