TERT Polyclonal Antibody | G-AB-05052
Gentaur Antibodies
Write a Review
Gentaur Antibodies
TERT Polyclonal Antibody | G-AB-05052
- SKU:
- G-AB-05052
- Availability:
- 3 to 5 Working Days
- Host:
- Rabbit
- Reactivity:
- Human
TERT Polyclonal Antibody | G-AB-05052 | Gentaur Antibodies
Overview: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Developmental Biology, Stem Cells
Synonyms: CMM9, DKCA2, DKCB4, EST2, HEST2, htert, hTRT, PFBMFT1, TCS1, Telomerase associated protein 2, Telomerase catalytic subunit, Telomerase reverse transcriptase, Telomerase-associated protein 2, Telomere Reverse Transcriptase, TERT, TERT, TP2, TRT
Reactivity: Human
Host: Rabbit
Isotype: IgG
Gene ID:
Accession #: NP_937983
Clonality: Polyclonal
Immunogen: Synthetic peptide of human TERT
Clone #:
Conjugation: Unconjugated
Swissprot: O14746
Santa Cruz: sc-7214/sc-7215/sc-7212
Calculated MW: 127 kDa
Observed MW:
Concentration: 1.1 mg/mL
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Affinity purification
Application: WB, IHC, ELISA
Dilution: WB 1:200-1:1000, IHC 1:25-1:100
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Related Products
