TIAM1 Polyclonal Antibody | G-AB-07347

TIAM1 Polyclonal Antibody | G-AB-07347 | Gentaur Antibodies

Overview: This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF) . GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) . The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD) , and PSD-95/DlgA/ZO-1 (PDZ) domain.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: TIAM1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 7074

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human TIAM1 (NP_003244.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13009

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

TIAM1 Polyclonal Antibody DataSheet