TNFSF10 Polyclonal Antibody | G-AB-09964

TNFSF10 Polyclonal Antibody | G-AB-09964 | Gentaur Antibodies

Overview: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Cardiovascular

Synonyms: TNFSF10, APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 8743

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human TNFSF10 (NP_003801.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P50591

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

TNFSF10 Polyclonal Antibody DataSheet