UBE3A Polyclonal Antibody | G-AB-09707

UBE3A Polyclonal Antibody | G-AB-09707 | Gentaur Antibodies

Overview: This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.

Category Type: Polyclonal Antibody

Research Areas: Cell Biology, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms: UBE3A, ANCR, AS, E6-AP, EPVE6AP, HPVE6A

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 7337

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human UBE3A (NP_570853.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q05086

Santa Cruz:

Calculated MW: 97 kDa/100 kDa

Observed MW: 110 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

UBE3A Polyclonal Antibody DataSheet