WRN Polyclonal Antibody | G-AB-07074

WRN Polyclonal Antibody | G-AB-07074 | Gentaur Antibodies

Overview: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: DKFZp686C2056, DNA helicase, DNA helicase, RecQ like type 3, Exonuclease WRN, HGNC 12791, OTTHUMP00000225301, RecQ protein-like 2, RecQ-like type 3, RecQ3, RECQL2, RECQL3, Werner syndrome ATP-dependent helicase, Werner syndrome helicase, Werner syndrome protein, Werner syndrome, RecQ helicase like, WRN, WRN

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP000544

Clonality: Polyclonal

Immunogen: Synthetic peptide of human WRN

Clone #:

Conjugation: Unconjugated

Swissprot: Q14191

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 0.8 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

WRN Polyclonal Antibody DataSheet