XBP1 Polyclonal Antibody | G-AB-02157

XBP1 Polyclonal Antibody | G-AB-02157 | Gentaur Antibodies

Overview: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER) , the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1) . The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1 (S) , which is the functionally active transcription factor.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: Tax responsive element binding protein 5, Tax-responsive element-binding protein 5, TREB5, X box binding protein 1, X box binding protein 2, X-box-binding protein 1, XBP 1, XBP-1, XBP1, XBP1, XBP2

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC000938

Clonality: Polyclonal

Immunogen: Recombinant protein of human XBP1

Clone #:

Conjugation: Unconjugated

Swissprot: P17861

Santa Cruz: sc-32138/sc-32135/sc-32136/sc-7160

Calculated MW:

Observed MW:

Concentration: 0.2 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

XBP1 Polyclonal Antibody DataSheet