ZNF451 Polyclonal Antibody | G-AB-09062

ZNF451 Polyclonal Antibody | G-AB-09062 | Gentaur Antibodies

Overview: E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494) . Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro) . Required for MCM4 sumoylation (By similarity) . Has no activity with SUMO1 (PubMed:26524493) . Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493) . Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets.

Category Type: Polyclonal Antibody

Research Areas:

Synonyms: ZNF451, COASTER, dJ417I1.1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 26036

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ZNF451 (NP_001026794.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9Y4E5

Santa Cruz:

Calculated MW: 63 kDa/115 kDa/121 kDa

Observed MW: Refer to figures

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:200-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ZNF451 Polyclonal Antibody DataSheet