ZYX Polyclonal Antibody | G-AB-09962

ZYX Polyclonal Antibody | G-AB-09962 | Gentaur Antibodies

Overview: Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in Signal Transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in Signal Transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the Signal Transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.

Category Type: Polyclonal Antibody

Research Areas: Epigenetics and Nuclear Signaling, Neuroscience, Signal Transduction

Synonyms: ZYX, ESP-2, HED-2, zyxin

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 7791

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ZYX (NP_001010972.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q15942

Santa Cruz:

Calculated MW: 45 kDa/61 kDa

Observed MW: 78 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ZYX Polyclonal Antibody DataSheet