53BP1 Polyclonal Antibody | G-AB-10816
- 3 to 5 Working Days
- Human, Mouse, Rat
53BP1 Polyclonal Antibody | G-AB-10816 | Gentaur Antibodies
Overview: This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V (D) J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Synonyms: TP53BP1, 53BP1, TDRD30, TP53, p202, p53BP1
Reactivity: Human, Mouse, Rat
Gene ID: 7158
Immunogen: Recombinant fusion protein of human 53BP1 (NP_001135452.1) .
Calculated MW: 213 kDa/214 kDa
Observed MW: 255 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IHC, IF
Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
1 Review Hide Reviews Show Reviews
like their name Gentaur, their products are totally organic. No use of any harmful chemicals is really happy with the products.