53BP1 Polyclonal Antibody | G-AB-10816

53BP1 Polyclonal Antibody | G-AB-10816 | Gentaur Antibodies

Overview: This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V (D) J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: TP53BP1, 53BP1, TDRD30, TP53, p202, p53BP1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 7158

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human 53BP1 (NP_001135452.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q12888

Santa Cruz:

Calculated MW: 213 kDa/214 kDa

Observed MW: 255 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

53BP1 Polyclonal Antibody DataSheet