A2M Polyclonal Antibody | G-AB-09378

A2M Polyclonal Antibody | G-AB-09378 | Gentaur Antibodies

Overview: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Cardiovascular

Synonyms: A2M, A2MD, CPAMD5, FWP007, S863-7

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 2

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human A2M (NP_000005.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P01023

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

A2M Polyclonal Antibody DataSheet