ABAT Polyclonal Antibody | G-AB-10580
- 3 to 5 Working Days
- Human, Mouse, Rat
ABAT Polyclonal Antibody | G-AB-10580 | Gentaur Antibodies
Overview: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA) , an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Metabolism, Neuroscience, Signal Transduction
Synonyms: ABAT, GABA-AT, GABAT, NPD009
Reactivity: Human, Mouse, Rat
Gene ID: 18
Immunogen: Recombinant fusion protein of human ABAT (NP_001120920.1) .
Calculated MW: 56 kDa
Observed MW: 50 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IHC, IF
Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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