ABAT Polyclonal Antibody | G-AB-10580

ABAT Polyclonal Antibody | G-AB-10580 | Gentaur Antibodies

Overview: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA) , an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Metabolism, Neuroscience, Signal Transduction

Synonyms: ABAT, GABA-AT, GABAT, NPD009

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 18

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human ABAT (NP_001120920.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P80404

Santa Cruz:

Calculated MW: 56 kDa

Observed MW: 50 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC, IF

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ABAT Polyclonal Antibody DataSheet