ATM Polyclonal Antibody | G-AB-10892

ATM Polyclonal Antibody | G-AB-10892 | Gentaur Antibodies

Overview: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, ATM

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 472

Accession #:

Clonality:

Immunogen: A synthetic peptide of human ATM (NP_000042.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q13315

Santa Cruz:

Calculated MW: 350 kDa

Observed MW: 310 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:1000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

ATM Polyclonal Antibody DataSheet