ATM Polyclonal Antibody | G-AB-10892
- 3 to 5 Working Days
ATM Polyclonal Antibody | G-AB-10892 | Gentaur Antibodies
Overview: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Synonyms: AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, ATM
Gene ID: 472
Immunogen: A synthetic peptide of human ATM (NP_000042.3) .
Calculated MW: 350 kDa
Observed MW: 310 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:1000
Storage: Store at -20°C. Avoid freeze / thaw cycles.