Phospho-ATM (Ser1981) Polyclonal Antibody | G-AB-05847

Phospho-ATM (Ser1981) Polyclonal Antibody | G-AB-05847 | Gentaur Antibodies

Overview: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: A-T mutated, A-T mutated homolog, AT mutated, AT1, ATA, Ataxia telangiectasia mutated, Ataxia telangiectasia mutated gene, Ataxia telangiectasia mutated homolog (human) , Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, ATM, ATM serine/threonine kinase, ATM, DKFZp781A0353, MGC74674, OTTHUMP00000232981, Serine protein kinase ATM, Serine-protein kinase ATM, Serine/threonine-protein kinase ATM, Tefu, TEL1, TEL1, telomere maintenance 1, homolog, TELO1, Telomere fusion protein

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human Atm around the phosphorylation site of Ser1981

Clone #:

Conjugation: Unconjugated

Swissprot: Q13315

Santa Cruz: sc-7129/sc-7128/sc-1213/sc-1214/sc-1212/sc-7230/sc-15392/sc-28881

Calculated MW:

Observed MW: 350 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: WB, IHC-p, ELISA

Dilution: WB 1:500-1:2000, IHC 1:50-1:200, ELISA 1:5000-1:20000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-ATM (Ser1981) Polyclonal Antibody DataSheet