Caspase-5 Polyclonal Antibody | G-AB-09528

Caspase-5 Polyclonal Antibody | G-AB-09528 | Gentaur Antibodies

Overview: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.

Category Type: Polyclonal Antibody

Research Areas: Cell Biology

Synonyms: CASP5, ICE (rel) III, ICEREL-III, ICH-3, caspase-5

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 838

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human Caspase-5 (NP_001129584) .

Clone #:

Conjugation: Unconjugated

Swissprot: P51878

Santa Cruz:

Calculated MW: 49 kDa

Observed MW: 35 kDa/50 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Caspase-5 Polyclonal Antibody DataSheet