CEP57 Polyclonal Antibody | G-AB-06322

CEP57 Polyclonal Antibody | G-AB-06322 | Gentaur Antibodies

Overview: This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2) , sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Category Type: Polyclonal Antibody

Research Areas: Signal Transduction, Stem cells

Synonyms: Centrosomal protein 57kDa, Centrosomal protein of 57 kDa, Cep57, Cep57 protein, CEP57, FGF2 interacting protein, FGF2-interacting protein, KIAA0092, MVA2, PIG8, Proliferation inducing protein 8, Testis specific protein 57, Testis-specific protein 57, Translokin, TSP57

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC039711

Clonality: Polyclonal

Immunogen: Full length fusion protein

Clone #:

Conjugation: Unconjugated

Swissprot: Q86XR8

Santa Cruz:

Calculated MW: 57 kDa

Observed MW: Refer to figures

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CEP57 Polyclonal Antibody DataSheet