CLOCK Polyclonal Antibody | G-AB-10748

CLOCK Polyclonal Antibody | G-AB-10748 | Gentaur Antibodies

Overview: The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Neuroscience, Signal Transduction

Synonyms: CLOCK, KAT13D, bHLHe8

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 9575

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human CLOCK (NP_004889.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: O15516

Santa Cruz:

Calculated MW: 95 kDa

Observed MW: 110 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CLOCK Polyclonal Antibody DataSheet