CRACR2A Polyclonal Antibody | G-AB-04672

CRACR2A Polyclonal Antibody | G-AB-04672 | Gentaur Antibodies

Overview: Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.

Category Type: Polyclonal Antibody

Research Areas: Signal Transduction

Synonyms: Calcium release-activated calcium channel regulator 2A, CRAC channel regulator 2A, CRACR2A, EF hand calcium binding domain 4B, EF hand calcium binding domain containing protein 4B, EF-hand calcium-binding domain-containing protein 4B, EFC4B, EFCAB 4B, Efcab4b, FLJ33805, MGC4266

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: BC004524

Clonality: Polyclonal

Immunogen: Fusion protein of human CRACR2A

Clone #:

Conjugation: Unconjugated

Swissprot: Q9BSW2

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 0.84 mg/mL

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification method: Antigen affinity purification

Application: IHC, ELISA

Dilution: IHC 1:50-1:200, ELISA 1:5000-1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

CRACR2A Polyclonal Antibody DataSheet