E-Cadherin Monoclonal Antibody | G-AB-05392

E-Cadherin Monoclonal Antibody | G-AB-05392 | Gentaur Antibodies

Overview: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.

Category Type: Monoclonal Antibody

Research Areas: Cancer, Developmental Biology, Signal Transduction

Synonyms: Arc 1, CADH1, Cadherin 1, cadherin 1 type 1 E-cadherin, Cadherin1, CAM 120/80, CD 324, CD324, CD324 antigen, cdh1, CDHE, E-Cad/CTF3, E-cadherin, ECAD, Epithelial cadherin, epithelial calcium dependant adhesion protein, LCAM, Liver cell adhesion molecule, UVO, Uvomorulin

Reactivity: Mouse, Rat

Host: Mouse

Isotype: IgG

Gene ID:

Accession #:

Clonality: Monoclonal

Immunogen: Recombinant protein corresponding to MouseE-cadherin

Clone #: EC125D

Conjugation: Unconjugated

Swissprot: P09803, Q9R0T4

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1.6 mg/mL

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:200-1:800

Storage: Store at -20°C. Avoid freeze / thaw cycles.

E-Cadherin Monoclonal Antibody DataSheet