FBLN5 Polyclonal Antibody | G-AB-12456
- 3 to 5 Working Days
- Human, Mouse
FBLN5 Polyclonal Antibody | G-AB-12456 | Gentaur Antibodies
Overview: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I) , and age-related macular degeneration type 3 (ARMD3) .
Category Type: Polyclonal Antibody
Research Areas: Cardiovascular, Signal Transduction
Synonyms: FBLN5, ADCL2, ARCL1A, ARMD3, DANCE, EVEC, FIBL-5, HNARMD, UP50, fibulin-5
Reactivity: Human, Mouse
Gene ID: 10516
Immunogen: Recombinant fusion protein of human FBLN5 (NP_006320.2) .
Calculated MW: 50 kDa
Observed MW: 72 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IF
Dilution: WB 1:500-1:2000 IF 1:50-1:100
Storage: Store at -20°C. Avoid freeze / thaw cycles.