GNE Polyclonal Antibody | G-AB-12275
- 3 to 5 Working Days
- Human, Mouse, Rat
GNE Polyclonal Antibody | G-AB-12275 | Gentaur Antibodies
Overview: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc) , a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and Signal Transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.
Category Type: Polyclonal Antibody
Research Areas: Cardiovascular, Developmental Biology
Synonyms: GNE, DMRV, GLCNE, IBM2, NM, Uae1
Reactivity: Human, Mouse, Rat
Gene ID: 10020
Immunogen: Recombinant fusion protein of human GNE (NP_001121699.1) .
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: IHC 1:50-1:100
Storage: Store at -20°C. Avoid freeze / thaw cycles.