GNE Polyclonal Antibody | G-AB-12275

GNE Polyclonal Antibody | G-AB-12275 | Gentaur Antibodies

Overview: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc) , a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and Signal Transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms.

Category Type: Polyclonal Antibody

Research Areas: Cardiovascular, Developmental Biology

Synonyms: GNE, DMRV, GLCNE, IBM2, NM, Uae1

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 10020

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human GNE (NP_001121699.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q9Y223

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IHC

Dilution: IHC 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

GNE Polyclonal Antibody DataSheet