HIRA Polyclonal Antibody | G-AB-12213
- 3 to 5 Working Days
HIRA Polyclonal Antibody | G-AB-12213 | Gentaur Antibodies
Overview: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Developmental Biology, Stem Cells
Synonyms: HIRA, DGCR1, TUP1, TUPLE1
Gene ID: 7290
Immunogen: Recombinant fusion protein of human HIRA (NP_003316.3) .
Calculated MW: 89 kDa/111 kDa
Observed MW: 112 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IHC
Dilution: WB 1:500-1:2000 IHC 1:100-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.