HIRA Polyclonal Antibody | G-AB-12213

HIRA Polyclonal Antibody | G-AB-12213 | Gentaur Antibodies

Overview: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling, Developmental Biology, Stem Cells

Synonyms: HIRA, DGCR1, TUP1, TUPLE1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 7290

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human HIRA (NP_003316.3) .

Clone #:

Conjugation: Unconjugated

Swissprot: P54198

Santa Cruz:

Calculated MW: 89 kDa/111 kDa

Observed MW: 112 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:100-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

HIRA Polyclonal Antibody DataSheet