IL21R Polyclonal Antibody | G-AB-11704
- 3 to 5 Working Days
- Human, Mouse
IL21R Polyclonal Antibody | G-AB-11704 | Gentaur Antibodies
Overview: The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21) . It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Immunology
Synonyms: IL21R, CD360, NILR
Reactivity: Human, Mouse
Gene ID: 50615
Immunogen: Recombinant fusion protein of human IL21R (NP_851565.4) .
Calculated MW: 59 kDa
Observed MW: 70 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Dilution: WB 1:500-1:2000
Storage: Store at -20°C. Avoid freeze / thaw cycles.