JAK2 Monoclonal Antibody | G-AB-05731

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$163.00 - $465.00
3 to 5 Working Days
Human, Mouse, Rat
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JAK2 Monoclonal Antibody | G-AB-05731 | Gentaur Antibodies

Overview: Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. In the cytoplasm, plays a pivotal role in Signal Transduction via its association with cytokine receptors, which constitutes an initiating step in signaling for many members of the cytokine receptor superfamily including the receptors for growth hormone (GHR) , prolactin (PRLR) , leptin (LEPR) , erythropoietin (EPOR) , granulocyte-macrophage colony-stimulating factor (CSF2) , thrombopoietin (THPO) and multiple interleukins. Following stimulation with erythropoietin (EPO) during erythropoiesis, it is autophosphorylated and activated, leading to its association with erythropoietin receptor (EPOR) and tyrosine phosphorylation of residues in the EPOR cytoplasmic domain. Also involved in promoting the localization of EPOR to the plasma membrane. Also acts downstream of some G-protein coupled receptors. Plays a role in the control of body weight (By similarity) . Mediates angiotensin-2-induced ARHGEF1 phosphorylation. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph) , a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.

Category Type: Monoclonal Antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms: JAK 2, JAK-2, JAK2, JAK2, Janus Activating Kinase 2, Janus kinase 2 (a protein tyrosine kinase) , Janus kinase 2, JTK 10, JTK10, kinase Jak2, OTTHUMP00000043260, THCYT3, Tyrosine protein kinase JAK2, Tyrosine-protein kinase JAK2

Reactivity: Human, Mouse, Rat

Host: Mouse

Isotype: IgG

Gene ID:

Accession #:

Clonality: Monoclonal

Immunogen: Synthetic Peptide of JAK2

Clone #: Clone:3F10

Conjugation: Unconjugated

Swissprot: O60674

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.

Purification method: Protein A purification

Application: IHC-p

Dilution: IHC 1:50-300

Storage: Store at -20°C. Avoid freeze / thaw cycles.

JAK2 Monoclonal Antibody DataSheet

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