JAK2 Polyclonal Antibody | G-AB-05962

JAK2 Polyclonal Antibody | G-AB-05962 | Gentaur Antibodies

Overview: Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. In the cytoplasm, plays a pivotal role in Signal Transduction via its association with cytokine receptors, which constitutes an initiating step in signaling for many members of the cytokine receptor superfamily including the receptors for growth hormone (GHR) , prolactin (PRLR) , leptin (LEPR) , erythropoietin (EPOR) , granulocyte-macrophage colony-stimulating factor (CSF2) , thrombopoietin (THPO) and multiple interleukins. Following stimulation with erythropoietin (EPO) during erythropoiesis, it is autophosphorylated and activated, leading to its association with erythropoietin receptor (EPOR) and tyrosine phosphorylation of residues in the EPOR cytoplasmic domain. Also involved in promoting the localization of EPOR to the plasma membrane. Also acts downstream of some G-protein coupled receptors. Plays a role in the control of body weight (By similarity) . Mediates angiotensin-2-induced ARHGEF1 phosphorylation. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph) , a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell biology, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms: JAK 2, JAK-2, JAK2, JAK2, Janus Activating Kinase 2, Janus kinase 2 (a protein tyrosine kinase) , Janus kinase 2, JTK 10, JTK10, kinase Jak2, OTTHUMP00000043260, THCYT3, Tyrosine protein kinase JAK2, Tyrosine-protein kinase JAK2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human JAK2 around the non-phosphorylation site of Tyr1007.

Clone #:

Conjugation: Unconjugated

Swissprot: O60674

Santa Cruz: sc-34479/sc-34480/sc-278/sc-294/sc-7229

Calculated MW: 131 kDa

Observed MW: 130 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: WB, IHC-p, IF, ELISA

Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:10000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

JAK2 Polyclonal Antibody DataSheet

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