(KO Validated) Caspase-3 Polyclonal Antibody | G-AB-09979

(KO Validated) Caspase-3 Polyclonal Antibody | G-AB-09979 | Gentaur Antibodies

Overview: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Cell Biology, Metabolism, Neuroscience

Synonyms: CPP32, CPP32B, SCA-1, Active Caspase 3, CASP3, active Caspase-3, Caspase 3, Caspase-3 p12, caspase-3

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 836

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human Caspase-3 (NP_004337.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P42574

Santa Cruz:

Calculated MW: 31 kDa

Observed MW: 17 kDa/35 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

(KO Validated) Caspase-3 Polyclonal Antibody DataSheet