(KO Validated) NUDT1 Polyclonal Antibody | G-AB-08165
- 3 to 5 Working Days
(KO Validated) NUDT1 Polyclonal Antibody | G-AB-08165 | Gentaur Antibodies
Overview: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.
Category Type: Polyclonal Antibody
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Synonyms: NUDT1, MTH1
Gene ID: 4521
Immunogen: Recombinant fusion protein of human NUDT1 (NP_945192.1) .
Calculated MW: 17 kDa/19 kDa/20 kDa/22 kDa
Observed MW: 18 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IHC
Dilution: WB 1:500-1:2000 IHC 1:50-1:200
Storage: Store at -20°C. Avoid freeze / thaw cycles.
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