(KO Validated) DNMT1 Polyclonal Antibody | G-AB-10690

(KO Validated) DNMT1 Polyclonal Antibody | G-AB-10690 | Gentaur Antibodies

Overview: This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI, DNMT1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 1786

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human DNMT1 (NP_001370.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P26358

Santa Cruz:

Calculated MW: 144 kDa/183 kDa/184 kDa

Observed MW: 200 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IF

Dilution: WB 1:500-1:2000 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

(KO Validated) DNMT1 Polyclonal Antibody DataSheet