(KO Validated) NUDT1 Polyclonal Antibody | G-AB-08165

(KO Validated) NUDT1 Polyclonal Antibody | G-AB-08165 | Gentaur Antibodies

Overview: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: NUDT1, MTH1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 4521

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human NUDT1 (NP_945192.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: P36639

Santa Cruz:

Calculated MW: 17 kDa/19 kDa/20 kDa/22 kDa

Observed MW: 18 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IHC

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

(KO Validated) NUDT1 Polyclonal Antibody DataSheet