MCM10 Polyclonal Antibody | G-AB-10650

MCM10 Polyclonal Antibody | G-AB-10650 | Gentaur Antibodies

Overview: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Category Type: Polyclonal Antibody

Research Areas: Epigenetics and Nuclear Signaling

Synonyms: MCM10, CNA43, DNA43, PRO2249

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Gene ID: 55388

Accession #:

Clonality:

Immunogen: Recombinant fusion protein of human MCM10 (NP_877428.1) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q7L590

Santa Cruz:

Calculated MW:

Observed MW:

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: IF

Dilution: IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

MCM10 Polyclonal Antibody DataSheet