NPHS1 Polyclonal Antibody | G-AB-01360

NPHS1 Polyclonal Antibody | G-AB-01360 | Gentaur Antibodies

Overview: This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180-kDa protein in lysates of human glomeruli and a 150-kDa protein in transfected COS-7 cell lysates.

Category Type: Polyclonal Antibody

Research Areas: Cancer, Signal Transduction

Synonyms: CNF, Nephrin, Nephrosis 1 congenital Finnish type, Nephrosis 1, congenital, Finnish type (nephrin) , NPHN, NPHN, NPHS 1, Nphs1, Renal glomerulus specific cell adhesion receptor, Renal glomerulus-specific cell adhesion receptor

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #: NP_004637

Clonality: Polyclonal

Immunogen: Synthetic peptide of human NPHS1

Clone #:

Conjugation: Unconjugated

Swissprot: O60500

Santa Cruz: sc-19000/sc-32529/sc-32530/sc-32532/sc-28192

Calculated MW: 135 kDa

Observed MW:

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Application: WB, IHC, ELISA

Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

NPHS1 Polyclonal Antibody DataSheet