Phospho-CHEK1 (S317) Polyclonal Antibody | G-AB-12477

Phospho-CHEK1 (S317) Polyclonal Antibody | G-AB-12477 | Gentaur Antibodies

Overview: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: CHEK1, CHK1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 1111

Accession #:

Clonality:

Immunogen: A synthetic phosphorylated peptide around S317 of human CHEK1 (NP_001265.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: O14757

Santa Cruz:

Calculated MW: 43 kDa/50 kDa/54 kDa

Observed MW: 60 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IF

Dilution: WB 1:500-1:2000 IF 1:50-1:200

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-CHEK1 (S317) Polyclonal Antibody DataSheet