Phospho-CHEK2 (Thr68) Polyclonal Antibody | G-AB-05744

Phospho-CHEK2 (Thr68) Polyclonal Antibody | G-AB-05744 | Gentaur Antibodies

Overview: Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Epigenetics and Nuclear Signaling

Synonyms: CDS 1, Cds1, Cds1 homolog, Checkpoint kinase 2, Checkpoint like protein CHK2, CHEK 2, Chek2, Chk 2, CHK2 checkpoint homolog (S. pombe) , CHK2 checkpoint homolog, CHK2, hCds1, HuCds 1, LFS 2, LFS2, PP1425, RAD 53, RAD53, Rad53 homolog, Serine/threonine protein kinase Chk2, Serine/threonine-protein kinase Chk2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID:

Accession #:

Clonality: Polyclonal

Immunogen: Synthesized peptide derived from human Chk2 around the phosphorylation site of Thr68

Clone #:

Conjugation: Unconjugated

Swissprot: O96017

Santa Cruz:

Calculated MW: 61 kDa

Observed MW: 61 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification method: Affinity purification

Application: WB, IHC-p, IF, ELISA

Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:10000-1:20000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-CHEK2 (Thr68) Polyclonal Antibody DataSheet