Phospho-FLT3 (Y589/591) Polyclonal Antibody | G-AB-12589

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Phospho-FLT3 (Y589/591) Polyclonal Antibody | G-AB-12589 | Gentaur Antibodies

Overview: This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Category Type: Phosphorylated antibody

Research Areas: Immunology, Signal Transduction

Synonyms: FLT3, CD135, FLK-2, FLK2, STK1

Reactivity: Human

Host: Rabbit

Isotype: IgG

Gene ID: 2322

Accession #:


Immunogen: A synthetic phosphorylated peptide around Y589 & Y591 of human FLT3 (NP_004110.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: P36888

Santa Cruz:

Calculated MW: 108 kDa/112 kDa

Observed MW: 113 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB

Dilution: WB 1:500-1:2000

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-FLT3 (Y589/591) Polyclonal Antibody DataSheet