Phospho-MDM2 (S166) Polyclonal Antibody | G-AB-12496

Phospho-MDM2 (S166) Polyclonal Antibody | G-AB-12496 | Gentaur Antibodies

Overview: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Category Type: Phosphorylated antibody

Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms: MDM2, ACTFS, HDMX, hdm2

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Gene ID: 4193

Accession #:

Clonality:

Immunogen: A synthetic phosphorylated peptide around S166 of human MDM2 (NP_002383.2) .

Clone #:

Conjugation: Unconjugated

Swissprot: Q00987

Santa Cruz:

Calculated MW: 11-14 kDa/24-55 kDa

Observed MW: 95 kDa

Concentration: 1 mg/mL

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification method: Affinity purification

Application: WB, IF

Dilution: WB 1:500-1:1000 IF 1:50-1:100

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Phospho-MDM2 (S166) Polyclonal Antibody DataSheet