Phospho-MDM2 (S166) Polyclonal Antibody | G-AB-12496
- 3 to 5 Working Days
- Human, Mouse, Rat
Phospho-MDM2 (S166) Polyclonal Antibody | G-AB-12496 | Gentaur Antibodies
Overview: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Category Type: Phosphorylated antibody
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Synonyms: MDM2, ACTFS, HDMX, hdm2
Reactivity: Human, Mouse, Rat
Gene ID: 4193
Immunogen: A synthetic phosphorylated peptide around S166 of human MDM2 (NP_002383.2) .
Calculated MW: 11-14 kDa/24-55 kDa
Observed MW: 95 kDa
Concentration: 1 mg/mL
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification method: Affinity purification
Application: WB, IF
Dilution: WB 1:500-1:1000 IF 1:50-1:100
Storage: Store at -20°C. Avoid freeze / thaw cycles.