Phospho-NFAT2 (Ser294) Antibody | 796-AF8012
Species Reactivity Human, Mouse
Host/Isotype Rabbit / IgG
Immunogen A synthesized peptide derived from human NFAT2 (Phospho-Ser294)
Concentration 1 mg/mL
Purification Affinity chromatography
Storage buffer PBS, pH 7.4, with 50% glycerol
Contains 0.02% sodium azide
Storage conditions -20°C
Product Specific Information
Phospho-NFATC2 (Ser294) Polyclonal Antibody detects endogenous levels of NFATC2 only when phosphorylated at Ser294.
The nuclear factor of activated T-cells (NFAT) transcription complex is required for the expression of a group of proteins that collectively regulate the immune response. Four NFAT proteins, encoded on separate genes and expressed as several splice variants, have been described: NFAT1 (also known as NFATp or NFATc2), NFAT2 (NFATc or NFATc1), NFAT3, and NFAT4 (NFATx or NFATc3).
These proteins show a low level of sequence similarity with the Dorsal/Rel/NFkB family of transcription factors. Another NFAT-related protein termed NFAT5 differs from isoforms 1-4 in that it lacks many of the Fos/Jun contact sites observed in its predecessors and its subcellular localization is not calcineurin-dependent.